Influence of Platelet-Rich Fibrin on the Healing Potential of Nano-Hydroxyapatite in Endodontic Retreatment: An Experimental Study
DOI:
https://doi.org/10.64229/r2nxdt69Keywords:
Nano-hydroxyapatite, Platelet-rich Fibrin, Periapical Tissue Regeneration, Osteogenesis, Angiogenesis, Regenerative Biomaterials, Endodontic RetreatmentAbstract
Persistent periapical lesions present a major challenge in endodontic retreatment, often requiring innovative biologically based interventions to achieve predictable healing. Nano-hydroxyapatite (nHA) has emerged as a promising bone substitute due to its nanoscale architecture, excellent biocompatibility, and osteoconductive properties. However, its regenerative effect may be further enhanced when combined with platelet-rich fibrin (PRF), an autologous biomaterial that provides a reservoir of growth factors and cytokines crucial for tissue regeneration. This experimental study investigates the role of PRF in modulating the healing potential of nHA during endodontic retreatment. By comparing nHA alone and nHA supplemented with PRF in terms of periapical bone repair, inflammatory response, and tissue integration, the study highlights the synergistic advantages of combining a scaffold-based material with a biologically active matrix. Findings suggest that the incorporation of PRF significantly improves periapical healing dynamics, accelerates new bone formation, and enhances long-term treatment predictability, underscoring its value in regenerative endodontics.
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